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Investigation into Lupron Side Effects (Leuprolide Acetate)

Public Comments (5,065)
  • Sep 10th, 2014
    Someone from New York, NY writes:
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    I am a Lupron patient. It is unbelievable that drugs are being prescribed without full knowledge of effects and side effects. Long term studies are long overdue!
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  • Sep 10th, 2014
    Someone from Kansas City, MO writes:
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    Do NOT allow children to have this on label or off label. Juveniles brains form during puberty which is why we don't try them as adults... Lupron will never allow the brain to develop fully. They use the argument that kids are suicidal... that is one of the SIDE EFFECTS of this drug which has been shown to be non reversible after 2 weeks. Do NOT use our children as experiments.
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  • Sep 10th, 2014
    Someone from West Palm Beach, FL writes:
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    This shot is awful and should be taken off the market.
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  • Sep 10th, 2014
    Someone from Clarksville, TN signed.
  • Sep 8th, 2014
    Someone from Watervliet, NY writes:
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    I was put on Lupron Depot in 1992-1993 for 18 consecutive months, I have had numerous health issues and I was told at the time 6 months was the longest anyone had been on the medication.
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  • Sep 8th, 2014
    Someone from Las Vegas, NV signed.
  • Sep 8th, 2014
    Someone from Columbus, OH writes:
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    I took Lupron Depot Injections back in 1999 - 2000 for endometriosis by a physician in Columbus, Ohio, and now have ADHD, Severe Anxiety Disorder, Chronic Major Depressive Disorder, Fibromyalgia, Osteopenia, Postherpetic Neuralgia and Vitamin D Deficiency (as low as 15). Now, I am at the point of filing for disability as I am unable to hold a job for more than 2 yrs due to my conditions. I am curious to know if the Lupron medications could have caused my current health issues.
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  • Sep 8th, 2014
    Someone from Terril, IA writes:
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    I was treated with Lupron twice. The first time was after a laparoscopy for endometriosis and the second time was after a supra cervical hysterectomy due to the return of the endometriosis. I was warned of the temporary menopausal side effects of hot flashes, mood swings, etc. and even given a pamphlet to read! Never once was I warned of the dangers of the long term side effects; but I learned of these while researching my "mystery" symptoms years after my second treatment. Now 8 years after my second treatment, I'm suffering from joint pains, memory loss, major depression, and many more symptoms on top of the endometriosis I still suffer from. I am so angry not only because I was given a drug that I wasn't warned of the dangers, but also because now I am beginning to learn and realize that my over physical and mental health as well as the quality of my life will most likely worsen as I continue to deal with the pain of my disease!! Yes I know that as a consumer we should have the ability and right to research the options we are given by a doctor, but not every one has the access to the tools to do that. Most importantly, isn't it the doctors duty and the drug companies responsibility to educate us so that we are confident in making these life changing decisions about our health?
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  • Sep 7th, 2014
    Someone from Virginia Beach, VA signed.
  • Sep 6th, 2014
    Someone from Glendale, CA signed.
  • Sep 5th, 2014
    Someone from Carson, CA signed.
  • Sep 5th, 2014
    Someone from West Burlington, IA writes:
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    This drug is dangerous. I would like to see the kickback these drs are getting for prescribing it. It was given to me in the office and the only thing I was told is that it would put me in early menopause. It was given to me at Iowa University.
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  • Sep 5th, 2014
    Someone from Winfield, KS signed.
  • Sep 4th, 2014
    Someone from Ringgold, GA writes:
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    I went through 6 months of Lupron 17 years ago & I have long term side effects. It sucks!
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  • Sep 4th, 2014
    Someone from Brooklyn, NY writes:
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    Lupron is not candy, although the way doctor's like to give it out one would think that it is. It's a very toxic drug that has horrid side effects. I have unbearable hot flashes, memory loss and debilltating bone pain Some of the pain has subsided but i still feel out of sorts. And the worst thing of all IT DOES NOTHING TO HELP ALLEVIATE THE PAIN FROM ENDO. It's just a stopgap measure that doctor's prescribe because they can. It cures nothing and when you stop taking it the pain from Endometriosis comes right back. More clinical trials and studies need to be conducted and results published. It's not in our heads. This pain and discomfort is real. Women deserve better.
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  • Sep 4th, 2014
    Someone from Acworth, GA signed.
  • Sep 3rd, 2014
    Someone from Holtsville, NY writes:
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    Was being treated with lupron for 7 months. Made my RA 100x worse and at this point the pain is unreal. 39 and feel like I'm 90. Every joint kills. Feels like every bone is crushed as I try to move them. Doctors say No...it's out of your system now. This is your Ra! I've been controlled for years until I started this nightmare Drug. Praying it gets better because this is no way to live your life.
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  • Sep 2nd, 2014
    Someone from El Paso, TX writes:
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    I am a Lupron Depot patient. At first no doctor believe my pain was real, I was even sent to a mental hospital, it was really horrible. Anyway, finally a doctor believing in me did surgery and found the endometriosis, with other problems. After the surgery he put me on Lupron, and before he did, he gave me information for me to study before making the decision. I accepted, I was sent to Endofacts.com. Six months after the shots he did not give me any follow ups, just birth control, and I was on it for a month, and I was still on a lot of pain. I finally went to his office and told him I was in so much pain. He mentioned it was my appendix, and so another surgery, where he found more endometriosis. He said I should take Lurpon again, since it seem to clam the pain down, which it kind of did. Anyway, I have been on it for a month again, it has been less than a year since the 6 month treatment, and I have been weak, my nails break easy, pain on my bones, infections on my bladder and vagina, pain, and mood changes. I don't know if it's the Lurpon Depot, or if it's my other health problems. I just ask for more testing on the drug, more research for us. Personally, I have a lot of potential, goals, and they are all to be a doctor in the future. I want to go back to school and find work, learn how to drive. I am a 21 year old that is a SLAVE to her pain! I don't want that to define me. I am a young military wife, I try hard to serve my husband as hard as he does this wonderful country, but sometimes he can't even sleep because at times he has to take me to the ER. When he was deployed he was nervous for my health, and I have try hard to get myself better for him. Now, I ask for me to be a NORMAL 21 year old, and just be independent. Thank you.
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  • Aug 30th, 2014
    Someone from Lake Worth, FL signed.
  • Aug 30th, 2014
    Someone from Elizabeth City, NC signed.
  • Aug 29th, 2014
    Someone from Boaz, AL writes:
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    I was given this years ago for treatment of endometriosis. I recieved at minimum 6 injections. I know am filing disability on crohns/depression/anxiety. I have in the past suffered from suicidal ideation. I currently suffer from short and long term memory loss. I have years of time that are missing to me. Knowing this is all possibly from this drug is disturbing and not even fair. I wasnt given these things as a list of possible side effects or I would have never let my dr give me these.
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  • Aug 29th, 2014
    Someone from Washougal, WA writes:
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    This drug has caused me many side effects, the one that has crippled me is depression! I have never been an emotional person and on this I pushed away the man I love & friends I cherish... I didn't originally worry about the side effects because I'm usually "hey it won't happen to me!" But it did... I have had 9 ovarian surgerys leading up to this drug. My dr convinced me it's my last hope to hold on to have a child someday... being on this drug I still want a child but if it's not meant to be for me I will cope! Please reevaluate yourself before starting this, I never could of thought it would affect me like it has!
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  • Aug 29th, 2014
    Someone from Little Elm, TX signed.
  • Aug 29th, 2014
    Someone from Mesquite, TX writes:
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    I received 2 lupron shots in s.ept-oct of 2001. It has destroyed my life. Im on disability because of it and the anxiety it causes. I have no short term memory, I forget words when I'm talking so I have trouble completing sentences. I forget what was told to me, for example where someone says they are going. I have to ask up to 3-5 before it sets in and then I will forget it 10 minutes later and ask again. My kids have to tell me things I have done or where we are going. I have no mapping in my memory bank. I cant go to one place and then another using memory of the streets around our town. I have to go back to the freeway or sometimes start back from home if I'm running errands. People get frustrated with me. I constantly repeat myself over and over. I have to describe something sometimes because I cant think of its proper name, as simple as the word "cup", I have to describe its function, ie "Its round, you drink out of it". I feel so stupid, I cant say what I think or remember what I just said. My phone has become my memory bank. I have to put important things immediately in my phone before I forget. I cant remember what #s to push when I'm on the phone and dealing with an automated system. Simple tasks are so frustrating because of my memory loss. I am 1/3 intelligent as I use to be. I use to be pretty smart! It has ruined my life in so many ways and I bet this comment will show how much trouble I have writing an intelligent description and I have had to stop several times so I can think of the word I was trying to use. This isnt all that it has done to me but I cant remember the rest. I also know this caused my upcoming divorce.
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  • Aug 28th, 2014
    Someone from Grand Rapids, MI signed.
  • Aug 28th, 2014
    Someone from Pine Grove, CO writes:
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    I'm suffering three years after taking Lupron. Will I ever have my life back?
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  • Aug 27th, 2014
    Someone from Aliquippa, PA writes:
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    I have witnessed this drug cause so many horrible side effects to my best friend and ruin her life. Please pull this from the market.
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  • Aug 27th, 2014
    Someone from Patchogue, NY signed.
  • Aug 26th, 2014
    Someone from Coats, NC writes:
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    I took Lupron for what was to be a 6 month short term menopause for endometriosis... which was more like 9 months. Here it is a few YEARS later and I suffer with major memory loss problems and I feel like this medicine has made me "stupid" because I can't think properly, I can't remember anything... I simply cannot function correctly. Not like I used to. That sort of thing makes a person pretty depressed. I just don't even know what to do anymore.
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  • Aug 26th, 2014
    Someone from La Vergne, TN writes:
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    I took Lupron injections for 9 months from 1992-93. I have extreme depression and anxiety. know have fibromyalgia, degenerative disk disease, and severe arthritis. I do think their is a link to this drug. So many women have had the same symptoms-yet not one have been reported as a side-effect to the FDA.
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  • Aug 26th, 2014
    Someone from Three Rivers, MA writes:
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    I am a basket case. I have been off for 1.5 months I am more depressed, I cry over everything and I just feel like I am crawling out of my skin. It's a great feeling..:(
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  • Aug 25th, 2014
    Someone from Layton, UT signed.
  • Aug 25th, 2014
    Someone from Midland, TX signed.
  • Aug 25th, 2014
    Someone from San Antonio, TX signed.
  • Aug 25th, 2014
    Someone from Parker, CO writes:
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    I suffer from long term side
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  • Aug 23rd, 2014
    Someone from Ft Mitchell, KY signed.
  • Aug 22nd, 2014
    Someone from Knoxville, TN signed.
  • Aug 21st, 2014
    Someone from Burgettstown, PA signed.
  • Aug 21st, 2014
    Someone from Brooklyn, NY signed.
  • Aug 21st, 2014
    Someone from New Cumberland, WV writes:
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    Lupron did nothing for me and I eventually had to undergo a hysterectomy when I was 30 years old. Also, it affected my teeth, resulting in broken ones and gum disease..I also never had a problem with joint pain or muscle aches, and was diagnosed with fibromyalgia a couple of years after the lupron treatment. Also was a greater degree of anxiety and depression.. Lupron should be banned. My sister has went through more than her share of rounds of it and it has done nothing for her. Women should not have to suffer through these side effects. More information should be given to patients on this less than adequate medication..
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