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Investigation into Lupron Side Effects (Leuprolide Acetate)

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The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.

Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.

It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.

We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.

Public Comments
Nov 27th, 2018
Debra H. from Lisbon, NY writes:
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I was told to “cure” my Endo I just had to try this drug..this was in the 80’s..I went through hell..now I have terrible joint problems..memory loss..etc..I’m scared.. This isn’t right that 40 yrs later ..this poison is still being pumped into women of all ages..some testimonies from girls as young as 12..doctors of course are receiving monies.vacations..etc..to pump poison.. Please..enough..it’s time for this pharmaceutical company to tell the truth..and pull this poison out of Endometriosis verbiage..
Nov 7th, 2018
K.D. O. from New York, NY writes:
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I took two trial of Lupron in 2008 and I have horrible memory loss. It’s started while being treated and was told that it would get better after treatments. It’s still difficult to retain almost any new information and impossible to recall old memories. My vision problems started around the same time; prior to treatment I had 20/20 vision.
Nov 7th, 2018
K.D. O. from New York, NY writes:
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I took two trial of Lupron in 2008 and I have horrible memory loss. It’s started while being treated and was told that it would get better after treatments. It’s still difficult to retain almost any new information and impossible to recall old memories. My vision problems started around the same time; prior to treatment I had 20/20 vision.
Nov 7th, 2018
K.D. O. from New York, NY writes:
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I took two trial of Lupron in 2008 and I have horrible memory loss. It’s started while being treated and was told that it would get better after treatments. It’s still difficult to retain almost any new information and impossible to recall old memories. My vision problems started around the same time; prior to treatment I had 20/20 vision.
Nov 2nd, 2018
Sarah M. from Manitou Springs, CO writes:
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I was put on lupron to induce menopause in January of 2018 and received my last shot April 30th, 2018. since March I have had memory trouble, severe joint pain, numb hands to the elbows, stiff knees with severe pain when bending, anxiety attacks, and shoulder dislocation of both shoulders. It is now November and while I can now feel most of my fingers and bend the knees with slightly less pain all the other symptoms are still raging. Lupron took one debilitating problem away and replaced it with another. I truly feel Lupron was not necessary, the doctor had surgically confirmed endometriosis during a hysterectomy, and making me wait a year to go through this drug process he insisted was necessary to get the oopherectomy has taken a year away, with no telling when my symptoms will subside. This is a nasty, horrible drug!
Oct 25th, 2018
Melissa B. from San Diego, CA writes:
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I took Lupron quarterly shots in 2016 and 2017 . I had 6 quarterly shots. During my time on it, I had bone, joint and muscle pain. I had mind fog and could not focus. My memory could not retain information. I feel sick and depressed. My lab results were out of control. My glucose numbers were reaching 350. My vision worsened. My insides felt hot. My doctors told me this will go away once I stop the shots. I stopped and waited for it to detox out of my system. My last shot was November 2017. I still have the symptoms and I have more. Researching this drug I found that it is chemo and it damages your healthy cells. I found that thousands of people who took this are experiencing a regression in health. It seems to be deteriorating their mental and physical health. I am not the same. I’m still hoping that I will get myself back. This drug is toxic and poison.
Oct 18th, 2018
Someone from Kailua Kona, HI writes:
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At the age of 28 (2 year's ago) I was diagnosed with endometriosis and shortly after agreed to lupron injections. I only got the first shot, was thrown into an artificial menopause and felt as though I was slowly being poisoned. A whole******storm of nasty side effects came with it. Now fast forward to now, my left side (side I got the shot in) has sever nervous system damage, my speech is delayed, my motor skills are off, I'm extremely forgetful (thing's I've known for year's) dizziness every day, even my teeth are now going down the drain. The lower back pain is horrible,and my joints hurt all the time now. I'm only 30 year's old, I didn't know it was a chemo drug......
Oct 11th, 2018
Someone from Marengo, IL writes:
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After one shot I'm having horrible side affects which include nausea, lack of appetite, fatigue, insomnia, anxiety, pain in hips and back, extremely painful period, coughing, hot flashes and chills, brain fog amongst other things. I was not told prior to the injection that this was a chemo drug. I was told I would only feel hot flashes and moodiness. This drug is a lie!
Aug 17th, 2018
Someone from Gig Harbor, WA writes:
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This drug only added to my daughters problems. She suffers much from very real long term side effects including an increase of white brain matter in her brain, extremely bad migraines, auto immune issues and much more.
Apr 11th, 2018
Melody A. from Clarington, OH writes:
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Was found to have Endometriosis around age 19. Suffered with severe menstraul pain along with heavy bleeding. Caused lots of health issues. Had several diagnostic laparoscopic procedures. Nothing helped the pain that took over my life. I can tolorate pain to a point. Then my obgyn explained how Lupron Depot injections for 6 months were the next step. I was told only other choice would be a total Hystorectomy. I was young and wanted to option of having a third child. So I took those shots once a month every 28 days. Side effects yeah lots and the cost high. If I only knew before taking them, well I wouldn't of. About 4 years later had emergency hysterectomy. Lupron Depot had caused extreme headaches, numbness all over, blurred vision, so many health issues never had until after I started injections. Even my teeth were affected. I am 44 now live in pain daily. I am now undergoing diagnostic tests for a brain tumor. Please do something so others don't use Lupron Depot without understanding all the risks involved.
Apr 10th, 2018
Judith E. from Cartersville, GA writes:
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I am a 51 years old and have 3 fibroids (2 the size ping pong balls and 1 the size of an orange). I was experiencing menorrhagia related to these fibroids. February 9, 2018 I told the obgyn physician I would like a depo provera shot to stop the bleeding until my partial hysterectomy surgery in a few months. I was told I should try Lupron to also help shrink the fibroids. The first month, I had no side effects. Four days after my second shot, I began to have arthralgia, myalgia, neuralgia. Terrible numbness, burning painful fingers, hands and arms. I feel like I have severe arthritis of the hands. I also feel like electrical shocks shooting down my legs at times, deep muscle and bone pain. I also have hot flashes and chills. The list goes on and on. This is only after two shots of this drug. Pain medicine is ineffective for this pain. Sometimes it feels as though the symptoms are waning only to return with a vengeance. I've already seen a neurologist about this thinking I was coming down with an autoimmune disease only to find out Lupron is the culprit! I have fibromyalgia but this pain far exceeds that pain. Prior to the Lupron injections, if my pain from fibromyalgia was a ten, it is now a 100. I'm afraid of the long term side effects. I would discourage anyone from trying this "medication". It's dangerous and should be taken off of the market...NOW!
Apr 10th, 2018
Judith E. from Cartersville, GA signed.
Apr 2nd, 2018
Carl R. from Hempstead, TX writes:
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I am a 50 years old female diagnosed with Rheumatoid Arthritis 2 years ago but have had symptoms for at least 20 years. I was taking methotrexate and Cymbalta, as well as infusions of Remicade, nothing worked for me. All my pain was from my waist down and certainly not something I can stand. The only treatment that has been successful has been the taking of RA herbal remedy i purchased from Best Health herbal centre. I now wake up every morning without pain. I have been pain-free period for more than 4 months. I have regular blood tests and do not experience any of the side effects from taking the herbal remedy. Thank God this works for me. I feel great!.
Mar 30th, 2018
Leah H. from Boynton Beach, FL signed.
Mar 15th, 2018
Alice F. from Martinsville, VA writes:
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My daughter just had her Histrelin implant taken out. It’s the same as the shots, just in an implant given out slowly. She had a new implant put in every year or so at UVA. During this time she has been suicidal, cut herself, mood swings from hell, over eating, intense bone pain, lethargy, and noted blurry vision. She just had the implant taken out. Now she is having bone pain in her chest. She is on depression medication and anxiety medication and she is going to end up being a drug addict if she leaves the house one day with this pain. I want more info not a bunch of bs. I am sick of reading peer reviewed documents. I want it straight. I develop websites for a living. I will make one for us. Email me theunbrandedinc@ gmail. com
Mar 12th, 2018
Lisa G. from Houston, TX writes:
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I was prescribed 6 months of Lupron shots for endometriosis in 1998. I was told that it was the ONLY way to treat endometriosis and sadly, I trusted my doctor. Due to the extreme side effects, I was only able to take 4 shots. I was lied to from the beginning. Not only did the side affects NEVER go away (I'm 53 now), but it made my endometriosis explode inside my body. Due to Lupron, I have a tumor on my pituitary gland, damage to both my adrenal and thyroid systems, Diabetes as well as other autoimmune diseases. The pain and exhaustion that I have had EVERY day since the first Lupron shots is unrelenting. This drug is horrible and inhumane. Please take it off the market so more people don't have to suffer like I have for the rest of my life.
Mar 8th, 2018
LeighAnna C. from Moncks Corner, SC writes:
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I’m 27. I feel like I’m 87. I received Lupron shots, for 2.5 years, 15cc’s every 21 days after being diagnosed with Precocious puberty. After being off the Lupron for about a year, I developed an ovarian cyst the size of a grapefruit. I had surgery on that and is been down hill ever since. I feel crazy, absolutely horrible, live in physical pain, and depression. I just had an MRI that ruled out a tumor on my pituitary gland. That’s when I came looking for answers and found you. After reading all the testimonies, I guess I should be thankful to simply be alive. need advice now
Feb 24th, 2018
Someone from Auburn, AL writes:
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I was given a 3 month injection of Lupin in August of 2017. In November I developed terrible joint and bone pain, DDD in back, vision problems, acne, loss of soft tissue, tooth and jaw pain, and many other horrible symptoms. This drug has ruined my life and the life of my family. The nanotechnology (microspheres) which are used in Lupron can cause toxicity and permanent changes to cells in the brain. This drug is VERY dangerous! Please take it off the market immediately!
Jan 11th, 2018
Someone from Chattanooga, TN writes:
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My daughter was prescribed Lupron for CPP in 2014 and has received monthly injections for almost 4 years. I have been repeatedly assured that there would be no long term side effects. I am just now realizing the risk I have taken with my child's health. Had I have known even the limited information I know now about Lupron, I never would have given it to my daughter. It's too late for my family, but further research is desperately needed on this drug and it's long term effects on children.
Jan 11th, 2018
Someone from Chattanooga, TN signed.
Jan 10th, 2018
Teddi Y. from Winterset, IA writes:
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This drug has ruined my sister’s life and I know she doesn’t want a single other person to go through what she has.
Jan 10th, 2018
Holly J. from Bothell, WA writes:
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Since my last injection of Lupron Depot in May of 2014, I have gone from being a very healthy and active woman to nearly disabled. I have been diagnosed with FIBROMYALGIA, Cyclic vomiting syndrome, hypermobility of the joints, Arthritis, Unexplained abdominal pain, breaking teeth, several strains, fractures, 60 pound weight gain, constant sweating, heart palpitations, memory loss, and feeling like I have the flu every single day of my life. I know I am just one of thousands of sufferers. TAP Pharmaceuticals needs to be held accountable for the thousands of lives they have ruined.
Jan 8th, 2018
Mary E. from South Houston, TX signed.
Jan 8th, 2018
Mary E. from South Houston, TX signed.
Jan 8th, 2018
Mary E. from South Houston, TX signed.
Jan 6th, 2018
Someone from Boca Raton, FL writes:
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I did this search to find out about Lupron after reading that is now given to transgender children to prevent “puberty” since I was given for fibroids. WOW having had taken this drug back in 1990 I too now wonder what I thought was “old age” (60) is the result of this drug, that was almost 30 years ago and seeing all these other post I cant believe i’ve Never been asked about it, It sounds like we need to stop giving this to children and find a safer option.
Jan 5th, 2018
Joni M. from Dublin, OH writes:
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I was given Lupron injections for several months in 2008 as treatment for pelvic pain. I was diagnosed 2017 with multiple myeloma, impaired immune function and severe osteoporosis, bone pain. It never did help my symptoms of pelvic pain. There must be a connection.
Jan 5th, 2018
Joni M. from Dublin, OH writes:
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I was given Lupron injections for several months in 2008 as treatment for pelvic pain. I was diagnosed 2017 with multiple myeloma, impaired immune function and severe osteoporosis, bone pain. It never did help my symptoms of pelvic pain. There must be a connection.
Jan 2nd, 2018
Amy G. from Duluth, GA signed.
Dec 16th, 2017
Alesia W. from Salt Lake City, UT signed.
Dec 14th, 2017
Someone from Mackinaw, IL writes:
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I started taking lupron in 2010 due to endometriosis and was told it would help me have a baby. I immediately became so depressed I was put on antidepressants and I've been on them ever since. I since have gained weight until I was over 200lbs, had relationship issues related to depression, quit a job from my depression that I worked at for almost 9 years. I was always average to skinny before. I have to take phentermine just to not gain weight. I've had testing done on cholesterol levels and my thyroid. My thyroid levels are low end of the normal range, My blood sugar was elevated and cholesterol was higher than average. I have a difficult time with short term memory, where my brain becomes so fogged, it takes me forever to remember what I was thinking just a minute ago. I recently started having very sharp pains in my joints, I have been to physical therapy for a Nerve problem in my back that has never fully went away, I have really bad legs cramping all the time, severe depression, severe headaches (I take tylenol daily), decreased hemoglobin levels, hot flashes have happened a couple times, I have been to ER for dizziness, I am ALWAYS tired, and am concerned it may have affected my bone density. This product SHOULD NOT be on the market. I have taken 3-4 injections shots given at my Dr office beginning in 2010. They were the 3 month shots and roughly lasted 5 months.
Dec 7th, 2017
Kimberly R. from Delray Beach, FL writes:
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My son was given Lupron at 11 years old for precocious puberty! He started complaining of leg cramping about every other month. He then would develop a fever for about a week at a time every other month. He got Bell's palsy, and his moods were off the charts. The endocrinologist insisted it was NOT from the Lupron. After 6 months I took him off of it and he no longer got sick. Now he is 20, and suffers from anxiety, depression, and muscle aches. He did not have any of this before the Lupron.
Nov 27th, 2017
Amanda M. from Corning, IA writes:
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I feel like I’ve been fighting for my life ever since I took this drug,3 injections total, for uterine fibroids. Thyroid problems, body pain & fatigue Overall unhealthy state of physical being
Nov 23rd, 2017
Olga M. from Morrisville, NC writes:
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This drug is poison with horrible side effects. I barely can walk due to excruciating pain in my feet caused by only 1 Lupron ejection. Headache, nausea, ache and body pain, stomach issues, weight gain, the list goes on. Kill Lupron because Lupron kills!
Nov 15th, 2017
Sarah M. from Perrysville, IN signed.
Nov 4th, 2017
Kasia C. from Petaluma, CA writes:
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This "medicine" is pure poison! It has left me and my Father with permanent side effects!! Not to mention, this medicine does NOT stop progression or Endo, it doesn't shrink Endo lesions, it does not eradicate the disease in any way shape or form! While some may experience relief in Peritoneal Quality Pain, it is a band-aid at best! It's time to stop perpetuating the false, 100 year old theory regarding Endo! The treatment with the highest success rate is Expert Excision!!!
Nov 3rd, 2017
Cindy Y. from Forked River, NJ writes:
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This drug is absolute POISON!! How it is still on the market just shows how corrupt the FDA and our government is! This drug has ruined my life! Shame on all of those who are allowing this to continue to destroy lives!
Nov 2nd, 2017
Someone from Oswego, NY writes:
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Lupron for endometriosis is the stuff of nightmares, on so many levels. It is unjust to do this to women. We need those in authority to speak up.
Oct 31st, 2017
Salley A. from Oxford, MS writes:
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Please take action.
Oct 24th, 2017
Someone from Erie, MI writes:
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How is this drug not being pulled it’s ruined so many lives!

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