Investigation into Lupron Side Effects (Leuprolide Acetate)

Long Term Side Effects of Lupron Depot (Leuprolide Acetate

The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.



Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.



It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.



We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.




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Public Comments (5,063)
Jun 9th, 2019
Melissa B. from San Diego, CA writes:
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I was on Lupron quarterly Injections for 2 years. I was told that Lupron would put me into temporary menopause. I was diagnosed with Complex Hyperplasia without Atapia, precancerous cells and had some polyps. The Lupron Injections were supposed to stop the heavy bleed out cycles and then I’d be prepared for a hysterectomy. The shots made me sick. I wanted to stop but I was told the side effects were temporary and they would go away once I stopped. When the side effects became severe, I never went back for my next quarterly. I waited 3 -6 months and my side effects heightened rather than diminish. It’s been over a year and everyday I’m feeling new post Lupron side effects on top of the side effects I already had. This drug is poison. There are so many people with the same symptoms and our medical teams offer no support. I have no energy, my joints, bones and muscles hurt. I’m tired all the time. I feel like I aged 20 years and I have many other health issues. This drug took away my livelihood. This should not be injected or used.
Jun 9th, 2019
Melissa B. from San Diego, CA writes:
Quotation mark icon
I was on Lupron quarterly Injections for 2 years. I was told that Lupron would put me into temporary menopause. I was diagnosed with Complex Hyperplasia without Atapia, precancerous cells and had some polyps. The Lupron Injections were supposed to stop the heavy bleed out cycles and then I’d be prepared for a hysterectomy. The shots made me sick. I wanted to stop but I was told the side effects were temporary and they would go away once I stopped. When the side effects became severe, I never went back for my next quarterly. I waited 3 -6 months and my side effects heightened rather than diminish. It’s been over a year and everyday I’m feeling new post Lupron side effects on top of the side effects I already had. This drug is poison. There are so many people with the same symptoms and our medical teams offer no support. I have no energy, my joints, bones and muscles hurt. I’m tired all the time. I feel like I aged 20 years and I have many other health issues. This drug took away my livelihood. This should not be injected or used.
Jun 9th, 2019
Melissa B. from San Diego, CA writes:
Quotation mark icon
I was on Lupron quarterly Injections for 2 years. I was told that Lupron would put me into temporary menopause. I was diagnosed with Complex Hyperplasia without Atapia, precancerous cells and had some polyps. The Lupron Injections were supposed to stop the heavy bleed out cycles and then I’d be prepared for a hysterectomy. The shots made me sick. I wanted to stop but I was told the side effects were temporary and they would go away once I stopped. When the side effects became severe, I never went back for my next quarterly. I waited 3 -6 months and my side effects heightened rather than diminish. It’s been over a year and everyday I’m feeling new post Lupron side effects on top of the side effects I already had. This drug is poison. There are so many people with the same symptoms and our medical teams offer no support. I have no energy, my joints, bones and muscles hurt. I’m tired all the time. I feel like I aged 20 years and I have many other health issues. This drug took away my livelihood. This should not be injected or used.
Jun 9th, 2019
Melissa B. from San Diego, CA writes:
Quotation mark icon
I was on Lupron quarterly Injections for 2 years. I was told that Lupron would put me into temporary menopause. I was diagnosed with Complex Hyperplasia without Atapia, precancerous cells and had some polyps. The Lupron Injections were supposed to stop the heavy bleed out cycles and then I’d be prepared for a hysterectomy. The shots made me sick. I wanted to stop but I was told the side effects were temporary and they would go away once I stopped. When the side effects became severe, I never went back for my next quarterly. I waited 3 -6 months and my side effects heightened rather than diminish. It’s been over a year and everyday I’m feeling new post Lupron side effects on top of the side effects I already had. This drug is poison. There are so many people with the same symptoms and our medical teams offer no support. I have no energy, my joints, bones and muscles hurt. I’m tired all the time. I feel like I aged 20 years and I have many other health issues. This drug took away my livelihood. This should not be injected or used.
Jun 9th, 2019
Melissa B. from San Diego, CA writes:
Quotation mark icon
I was on Lupron quarterly Injections for 2 years. I was told that Lupron would put me into temporary menopause. I was diagnosed with Complex Hyperplasia without Atapia, precancerous cells and had some polyps. The Lupron Injections were supposed to stop the heavy bleed out cycles and then I’d be prepared for a hysterectomy. The shots made me sick. I wanted to stop but I was told the side effects were temporary and they would go away once I stopped. When the side effects became severe, I never went back for my next quarterly. I waited 3 -6 months and my side effects heightened rather than diminish. It’s been over a year and everyday I’m feeling new post Lupron side effects on top of the side effects I already had. This drug is poison. There are so many people with the same symptoms and our medical teams offer no support. I have no energy, my joints, bones and muscles hurt. I’m tired all the time. I feel like I aged 20 years and I have many other health issues. This drug took away my livelihood. This should not be injected or used.
Jun 7th, 2019
Someone from Bakersfield, CA writes:
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I was diagnosed with primordial dwarfism "Russell Silver Syndrome" and has gastro problems as a infant. At 5 years old I had Early Puberty So I was put on Growth Hormone and Lupron years after I have severe joint pain, bad teeth, memory trouble academically always tired and reproductive issues. All they told my parents was I was gonna have pain at the injection site
Jun 2nd, 2019
Someone from Turlock, CA writes:
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My daughter who is now 18 was diagnosed with precocious puberty at the age of 2. She most likely was born with it, however she was not diagnosed until the age of 2. She had Lupron injections every 28 days until she was about 9 years old, at that time she switched from Lupron injections to the Suprellin LA implant until age 11. The last several months we have been in and out of doctors offices. My daughter has joint pain, swelling in her hand and wrist, lack of strength, lack of grip in her hands, numbness and tingling, she is moody, and sleeps a lot. None of the doctors we have been to can figure out what is going on. Some doctors have suggested that she may have fibromyalgia. Are next appointment is with a neurologist. However the more I read, the more I think Lupron is the problem.
Apr 23rd, 2019
Someone from La Canada Flintridge, CA writes:
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Took Lupron for 1+ year with "addback hormone therapy". 2 months in my teeth crumbled/disintegrated. Now 20+ yrs. later..permanently disabled ...burning bones/joints...deformed fingers worsening....type 2 diabetes onset 2 yrs ago (no prior history) ...daily migraines...low vitamin D levels (take 50,000 units/week) ...had 2 level lumbar & 2 level cervical fusions (2000 & 2003) ...I was VERY active showing horses...now in bed in pain a lot with NO pain relief. Thought Rheumatoid...tested negative yet severe bone/joint pain with rapidly deforming finger knuckles. .. NO teeth.(dentures). Resting heart rate is 110 at lowest!
Apr 22nd, 2019
Someone from Westwood, NJ writes:
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My doctor gave me a 3 month 11.25 mg shot for endo & U fibroids. She told me she gave the shot to many people and never had issues. Completely destroyed my life for the next year and continues to create health issues for me to this day. Severe pain in bones, memory loss, multiple heath issues, inflammation, triggered autoimmune issues. I went back to her about the side effects and she did nothing to help me. She never told me Lupron is a cancer chemotherapy drug.
Apr 14th, 2019
Michele M. from Riverview, FL writes:
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Received 6 months Lupron post laparoscopy for Endo in 1995 and here I am 24 years later still suffering. Bone loss in jaw, degenerative disc disease, all over pain in joints, super sensitive nerves, have been on medication for copd, medication for depression, it doesn't end. Get this poison eliminated please. My Dr gave me no warning. He told me I would be cured of Endo, I am not...That I would get typical side effects, like I was going through menopause. Not true....

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