Investigation into Lupron Side Effects (Leuprolide Acetate)

Long Term Side Effects of Lupron Depot (Leuprolide Acetate

The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.

Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.

It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.

We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.

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Public Comments (5,038)
3 hours ago
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Apr 11th, 2018
Melody A. from Clarington, OH writes:
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Was found to have Endometriosis around age 19. Suffered with severe menstraul pain along with heavy bleeding. Caused lots of health issues. Had several diagnostic laparoscopic procedures. Nothing helped the pain that took over my life. I can tolorate pain to a point. Then my obgyn explained how Lupron Depot injections for 6 months were the next step. I was told only other choice would be a total Hystorectomy. I was young and wanted to option of having a third child. So I took those shots once a month every 28 days. Side effects yeah lots and the cost high. If I only knew before taking them, well I wouldn't of. About 4 years later had emergency hysterectomy. Lupron Depot had caused extreme headaches, numbness all over, blurred vision, so many health issues never had until after I started injections. Even my teeth were affected. I am 44 now live in pain daily. I am now undergoing diagnostic tests for a brain tumor. Please do something so others don't use Lupron Depot without understanding all the risks involved.
Apr 10th, 2018
Judith E. from Cartersville, GA writes:
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I am a 51 years old and have 3 fibroids (2 the size ping pong balls and 1 the size of an orange). I was experiencing menorrhagia related to these fibroids. February 9, 2018 I told the obgyn physician I would like a depo provera shot to stop the bleeding until my partial hysterectomy surgery in a few months. I was told I should try Lupron to also help shrink the fibroids. The first month, I had no side effects. Four days after my second shot, I began to have arthralgia, myalgia, neuralgia. Terrible numbness, burning painful fingers, hands and arms. I feel like I have severe arthritis of the hands. I also feel like electrical shocks shooting down my legs at times, deep muscle and bone pain. I also have hot flashes and chills. The list goes on and on. This is only after two shots of this drug. Pain medicine is ineffective for this pain. Sometimes it feels as though the symptoms are waning only to return with a vengeance. I've already seen a neurologist about this thinking I was coming down with an autoimmune disease only to find out Lupron is the culprit! I have fibromyalgia but this pain far exceeds that pain. Prior to the Lupron injections, if my pain from fibromyalgia was a ten, it is now a 100. I'm afraid of the long term side effects. I would discourage anyone from trying this "medication". It's dangerous and should be taken off of the market...NOW!
Apr 10th, 2018
Judith E. from Cartersville, GA signed.
Apr 2nd, 2018
Carl R. from Hempstead, TX writes:
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I am a 50 years old female diagnosed with Rheumatoid Arthritis 2 years ago but have had symptoms for at least 20 years. I was taking methotrexate and Cymbalta, as well as infusions of Remicade, nothing worked for me. All my pain was from my waist down and certainly not something I can stand. The only treatment that has been successful has been the taking of RA herbal remedy i purchased from Best Health herbal centre. I now wake up every morning without pain. I have been pain-free period for more than 4 months. I have regular blood tests and do not experience any of the side effects from taking the herbal remedy. Thank God this works for me. I feel great!.
Mar 30th, 2018
Leah H. from Boynton Beach, FL signed.
Mar 29th, 2018
Laura G. from Tucson, AZ writes:
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I copied this from: "December 28, 2012 Dr. David Redwine posted on Facebook's Lupron Victims page the following paragraph: "FDA and Lupron: A year ago, I completed a very detailed review of the original studies which brought Lupron to market. The review was based on the studies which were entered as exhibits in the Klein case in Las Vegas in August 2011, although the plaintiff was not allowed to discuss the studies!! I found evidence of systematic 'data management issues' - the raw data did not always support the conclusions. In fact the raw data virtually never supported the major conclusions, but this was glossed over in summary tables and summary discussions, which were probably all the FDA had time and manpower to look at. I sent the review to the FDA a year ago. They have reassured me in emails over the last year that they are looking into my concerns and will let me know when they completed their review. Nothing has happened. A review that a single doctor compiled in 4 months has languished in the bowels of the FDA for over a year. It is time for women who have victims of Lupron to write the FDA and demand toknow what is happening with this review. Martin Kaufman is the person at the FDA who has been corresponding with me. His email address is: I have contacted my Oregon US Senators, and have given them the information in the review and asked them to prod the FDA, but only one of them wrote back ... [addendum by Dr. Redwine on same page at "3-19-13" states:] Mr. Kaufman at the FDA ... said that my review had undergone extensive primary review and was now undergoing secondary review and it would be a few more months" ... David Redwine, M.D. Bend Oregon."
Mar 15th, 2018
Alice F. from Martinsville, VA writes:
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My daughter just had her Histrelin implant taken out. It’s the same as the shots, just in an implant given out slowly. She had a new implant put in every year or so at UVA. During this time she has been suicidal, cut herself, mood swings from hell, over eating, intense bone pain, lethargy, and noted blurry vision. She just had the implant taken out. Now she is having bone pain in her chest. She is on depression medication and anxiety medication and she is going to end up being a drug addict if she leaves the house one day with this pain. I want more info not a bunch of bs. I am sick of reading peer reviewed documents. I want it straight. I develop websites for a living. I will make one for us. Email me theunbrandedinc@ gmail. com

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