Investigation into Lupron Side Effects (Leuprolide Acetate)

Long Term Side Effects of Lupron Depot (Leuprolide Acetate

The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.



Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.



It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.



We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.




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Public Comments (5,036)
Oct 11th, 2018
Someone from Marengo, IL writes:
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After one shot I'm having horrible side affects which include nausea, lack of appetite, fatigue, insomnia, anxiety, pain in hips and back, extremely painful period, coughing, hot flashes and chills, brain fog amongst other things. I was not told prior to the injection that this was a chemo drug. I was told I would only feel hot flashes and moodiness. This drug is a lie!
Aug 17th, 2018
Someone from Gig Harbor, WA writes:
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This drug only added to my daughters problems. She suffers much from very real long term side effects including an increase of white brain matter in her brain, extremely bad migraines, auto immune issues and much more.
Apr 11th, 2018
Melody A. from Clarington, OH writes:
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Was found to have Endometriosis around age 19. Suffered with severe menstraul pain along with heavy bleeding. Caused lots of health issues. Had several diagnostic laparoscopic procedures. Nothing helped the pain that took over my life. I can tolorate pain to a point. Then my obgyn explained how Lupron Depot injections for 6 months were the next step. I was told only other choice would be a total Hystorectomy. I was young and wanted to option of having a third child. So I took those shots once a month every 28 days. Side effects yeah lots and the cost high. If I only knew before taking them, well I wouldn't of. About 4 years later had emergency hysterectomy. Lupron Depot had caused extreme headaches, numbness all over, blurred vision, so many health issues never had until after I started injections. Even my teeth were affected. I am 44 now live in pain daily. I am now undergoing diagnostic tests for a brain tumor. Please do something so others don't use Lupron Depot without understanding all the risks involved.
Apr 10th, 2018
Judith E. from Cartersville, GA writes:
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I am a 51 years old and have 3 fibroids (2 the size ping pong balls and 1 the size of an orange). I was experiencing menorrhagia related to these fibroids. February 9, 2018 I told the obgyn physician I would like a depo provera shot to stop the bleeding until my partial hysterectomy surgery in a few months. I was told I should try Lupron to also help shrink the fibroids. The first month, I had no side effects. Four days after my second shot, I began to have arthralgia, myalgia, neuralgia. Terrible numbness, burning painful fingers, hands and arms. I feel like I have severe arthritis of the hands. I also feel like electrical shocks shooting down my legs at times, deep muscle and bone pain. I also have hot flashes and chills. The list goes on and on. This is only after two shots of this drug. Pain medicine is ineffective for this pain. Sometimes it feels as though the symptoms are waning only to return with a vengeance. I've already seen a neurologist about this thinking I was coming down with an autoimmune disease only to find out Lupron is the culprit! I have fibromyalgia but this pain far exceeds that pain. Prior to the Lupron injections, if my pain from fibromyalgia was a ten, it is now a 100. I'm afraid of the long term side effects. I would discourage anyone from trying this "medication". It's dangerous and should be taken off of the market...NOW!
Apr 10th, 2018
Judith E. from Cartersville, GA signed.
Apr 2nd, 2018
Carl R. from Hempstead, TX writes:
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I am a 50 years old female diagnosed with Rheumatoid Arthritis 2 years ago but have had symptoms for at least 20 years. I was taking methotrexate and Cymbalta, as well as infusions of Remicade, nothing worked for me. All my pain was from my waist down and certainly not something I can stand. The only treatment that has been successful has been the taking of RA herbal remedy i purchased from Best Health herbal centre. I now wake up every morning without pain. I have been pain-free period for more than 4 months. I have regular blood tests and do not experience any of the side effects from taking the herbal remedy. Thank God this works for me. I feel great!.
Mar 30th, 2018
Leah H. from Boynton Beach, FL signed.
Mar 15th, 2018
Alice F. from Martinsville, VA writes:
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My daughter just had her Histrelin implant taken out. It’s the same as the shots, just in an implant given out slowly. She had a new implant put in every year or so at UVA. During this time she has been suicidal, cut herself, mood swings from hell, over eating, intense bone pain, lethargy, and noted blurry vision. She just had the implant taken out. Now she is having bone pain in her chest. She is on depression medication and anxiety medication and she is going to end up being a drug addict if she leaves the house one day with this pain. I want more info not a bunch of bs. I am sick of reading peer reviewed documents. I want it straight. I develop websites for a living. I will make one for us. Email me theunbrandedinc@ gmail. com
Mar 12th, 2018
Lisa G. from Houston, TX writes:
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I was prescribed 6 months of Lupron shots for endometriosis in 1998. I was told that it was the ONLY way to treat endometriosis and sadly, I trusted my doctor. Due to the extreme side effects, I was only able to take 4 shots. I was lied to from the beginning. Not only did the side affects NEVER go away (I'm 53 now), but it made my endometriosis explode inside my body. Due to Lupron, I have a tumor on my pituitary gland, damage to both my adrenal and thyroid systems, Diabetes as well as other autoimmune diseases. The pain and exhaustion that I have had EVERY day since the first Lupron shots is unrelenting. This drug is horrible and inhumane. Please take it off the market so more people don't have to suffer like I have for the rest of my life.
Mar 8th, 2018
LeighAnna C. from Moncks Corner, SC writes:
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I’m 27. I feel like I’m 87. I received Lupron shots, for 2.5 years, 15cc’s every 21 days after being diagnosed with Precocious puberty. After being off the Lupron for about a year, I developed an ovarian cyst the size of a grapefruit. I had surgery on that and is been down hill ever since. I feel crazy, absolutely horrible, live in physical pain, and depression. I just had an MRI that ruled out a tumor on my pituitary gland. That’s when I came looking for answers and found you. After reading all the testimonies, I guess I should be thankful to simply be alive. need advice now

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