Investigation into Lupron Side Effects (Leuprolide Acetate)

Long Term Side Effects of Lupron Depot (Leuprolide Acetate

The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.



Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.



It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.



We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.




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Public Comments (5,054)
Apr 14th, 2019
Michele M. from Riverview, FL writes:
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Received 6 months Lupron post laparoscopy for Endo in 1995 and here I am 24 years later still suffering. Bone loss in jaw, degenerative disc disease, all over pain in joints, super sensitive nerves, have been on medication for copd, medication for depression, it doesn't end. Get this poison eliminated please. My Dr gave me no warning. He told me I would be cured of Endo, I am not...That I would get typical side effects, like I was going through menopause. Not true....
Apr 13th, 2019
Christina G. from Placerville, CA writes:
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This poison has ruined my life. I'm only 30 but feel much, much older. As I'm typing this I'm in horrible pain. I took Lupron in 2014 after my first endometriosis surgery to be diagnosed. I did 6 shots for 6 months. It did not help with my endo pain at all and I remember going to my doctor asking for pain meds as I was in to much pain. I was also on depo. Now 5 years later I'm suffering and getting worse. I worse is the joint pain. Along with all over joint pain I have horrible back pain, headaches, fatigue, hair loss, worse vision, memory troubles, always cold, horrible sleep, gallbladder removed and gained 40 lbs in those 6 months. I can't just lay around in pain all day and can't take a lot of pain meds as I'm a mother of 4 and have to take care of them. I wish I would have lived through the endo pain and never put this poison into my body. This needs to be banned and now.
Mar 18th, 2019
Tracy H. from Milwaukee, WI writes:
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My daughter was prescribed this drug to "diagnosis" her thoracic endometriosis. Dr said it was the only way to know for sure it was endo since nothing was showing up on imagery. She was given two 3 month doses over a nine month period (3 month break in between doses). Her immediate side effects were mood swings, hot flashes, temporary leg paralysis (near end of 2nd dose), vision problems (blurry vision that comes and goes), rapid weight gain, brain fog, psoriasis, and migraines. Thankfully the majority of the side effects have subsided. But she is left with the migraines, vision problems, psoriasis, and the extra weight gain (similar to crushing's syndrome). To be fair, we were told about the hot flashes, possible mood swings, and the dangers of osteoporosis if given for longer than a year. NO way would I have agreed to the injections if I would have known about these other possible life long side effects. I did do some research, but apparently not enough and I trusted my daughter's Dr apparently too much.
Mar 15th, 2019
Valerie B. from Vancouver, WA writes:
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Medical professionals are conducting drug experiments on CHILDREN! We need to stop this nonsense, conduct scientifically sound studies BEFORE putting children on years long regimens. Outrageous!
Feb 26th, 2019
Audrey C. from Minco, OK writes:
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Lupron depot has ruin my life. It was to have helped to feel better but instead it has cause me nothing but hell. I had a very sharp and good memory could carry a conversation until the end. I was able to spell as I once did before I had taken the lupron injections. After I started taking it my health has kept declining since. I have developed a autoimmune disease, memory loss, loss of balance, unable to concentrate on the littles thing's. While engaged in a conversation with friends or family my mind draws a totally blank and I have no clue as to what we was discussing. I have bruises on my body everywhere. Anxiety,hot flashes as if I'm burning from the inside out, I also get very cold like I've been stuffed in a deep freeze and left for days. I tested positive for blood clotting at the emergency room. Was dc from the drug but still have issues and they seem to continue to decline each and every day.. So depressing
Feb 11th, 2019
Brittany F. from Minneapolis, MN writes:
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I was given a shot 3 weeks ago. I was told I’d have hot flashes and maybe some heavy bleeding. I was not told the drug attributes to insulin resistance. I’m a type 1 diabetic, my A1C has gone up 1.5%. Why wasn’t this thoroughly researched? Why wasn’t I warned?
Feb 11th, 2019
Brittany F. from Minneapolis, MN writes:
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I was given a shot 3 weeks ago. I was told I’d have hot flashes and maybe some heavy bleeding. I was not told the drug attributes to insulin resistance. I’m a type 1 diabetic, my A1C has gone up 1.5%. Why wasn’t this thoroughly researched? Why wasn’t I warned?
Feb 3rd, 2019
Inna L. from Brooklyn, NY writes:
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I had 4 injections of Lupron in 2015. Immediate side effects were - severe joint swelling and pain in my legs , arms, hands, heart palpitations, muscle weekness to the point , when my legs just would suddenly gove up causing me to fall. General fatigue, weight gain, hot flashes , insomnia, depression and anxiety. 4 years later i could not walk, pain did not leave for a day. I am going through hell. What makes the matters worst is that without an official admission of the harm that lupron causes doctors are free to deny or disregard my symptoms. This is my life that has been destroyed, my agonizing pain that been denied. I pray that God will make everyone responsible of prescribing or could be instrumental to remove this drug but chose not to take action would spent the eternity FEELING what i am feeling . STOP this drug. It hurts real people. Stop it.
Jan 9th, 2019
Heather P. from ROCKFORD, MI writes:
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I took lupron for endometriosis in 2011. I immediately has side effects that continue to harm me day to day. The memory fog and anxiety are the worst next to the muscle joint pain that I thought was from my job amd it has been ruled out. Thinking I might have fibromyalgia as I meet a lot of the symptoms. I cant even wear tight or fitting clothes as they cause me all over pain.
Jan 7th, 2019
Debbie N. from Bentonville, AR writes:
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I took 2 trials of Lupron for my endometreosis in 2003 to induce menopause. I have osteosrthritis and have broken several bones/teeth(had to take a year of Forteo), thyroid problems(calcium & vitamin D), lowered immune system problems, basal cell carcinona, melanoma diagnosis with several pre- melanoma close calls following. I have had 6 moh’s surgeries and too many skin biopsies to count. I am sick all of the time with colds/flu and am a frequent visitor to the Endocrinologist, Immunologist and Dermatologist. Lupron has ruined my life both personally and financially.

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