Investigation into Lupron Side Effects (Leuprolide Acetate)

Long Term Side Effects of Lupron Depot (Leuprolide Acetate

The purpose of this petition is to warn others regarding the drug Lupron (Leupolide Acetate) mfg. by Takeda/Abbott Pharmaceuticals in the hope that further long-term safety studies are done before it disables or kills more women. This drug was originally marketed to treat prostate cancer patients but now is widely used for the treatment of endometriosis, infertility, fibroids/ovarian cysts and even precocious puberty.



Many women are continuing to suffer the side effects long after taking their last dose even though their doctor and the pharmaceutical company states that the side effects should go away within 3-6 months. Side effects include but are not limited to: hot flashes, memory loss, tachycardia, hematura, hypotension, dizziness, insomnia, anxiety, depression, Vitamin D deficiency, constant gnawing bone/joint pain, osteoarthritis, osteopenia, osteoporosis, fibromyalgia, degenerative disc disease, autoimmune diseases, blood disorders, cancer and many others including death and yet not one long term study has been conducted.



It is devastating to us that we agreed to take an FDA approved drug under the care of our physician whom we trusted only to find ourselves sicker than you could imagine ---- in pain and unable to get the proper treatment or even believed that Lupron caused our problems.



We hereby request that an investigation be undertaken into the short term and long term effects of Lupron on women. We further request that all outcomes and results of such trials be released and published so that both patients and doctors alike may have the benefit of all the information regarding this drug.




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Public Comments (5,049)
Feb 11th, 2019
Brittany F. from Minneapolis, MN writes:
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I was given a shot 3 weeks ago. I was told I’d have hot flashes and maybe some heavy bleeding. I was not told the drug attributes to insulin resistance. I’m a type 1 diabetic, my A1C has gone up 1.5%. Why wasn’t this thoroughly researched? Why wasn’t I warned?
Feb 11th, 2019
Brittany F. from Minneapolis, MN writes:
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I was given a shot 3 weeks ago. I was told I’d have hot flashes and maybe some heavy bleeding. I was not told the drug attributes to insulin resistance. I’m a type 1 diabetic, my A1C has gone up 1.5%. Why wasn’t this thoroughly researched? Why wasn’t I warned?
Feb 3rd, 2019
Inna L. from Brooklyn, NY writes:
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I had 4 injections of Lupron in 2015. Immediate side effects were - severe joint swelling and pain in my legs , arms, hands, heart palpitations, muscle weekness to the point , when my legs just would suddenly gove up causing me to fall. General fatigue, weight gain, hot flashes , insomnia, depression and anxiety. 4 years later i could not walk, pain did not leave for a day. I am going through hell. What makes the matters worst is that without an official admission of the harm that lupron causes doctors are free to deny or disregard my symptoms. This is my life that has been destroyed, my agonizing pain that been denied. I pray that God will make everyone responsible of prescribing or could be instrumental to remove this drug but chose not to take action would spent the eternity FEELING what i am feeling . STOP this drug. It hurts real people. Stop it.
Jan 9th, 2019
Heather P. from ROCKFORD, MI writes:
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I took lupron for endometriosis in 2011. I immediately has side effects that continue to harm me day to day. The memory fog and anxiety are the worst next to the muscle joint pain that I thought was from my job amd it has been ruled out. Thinking I might have fibromyalgia as I meet a lot of the symptoms. I cant even wear tight or fitting clothes as they cause me all over pain.
Jan 7th, 2019
Debbie N. from Bentonville, AR writes:
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I took 2 trials of Lupron for my endometreosis in 2003 to induce menopause. I have osteosrthritis and have broken several bones/teeth(had to take a year of Forteo), thyroid problems(calcium & vitamin D), lowered immune system problems, basal cell carcinona, melanoma diagnosis with several pre- melanoma close calls following. I have had 6 moh’s surgeries and too many skin biopsies to count. I am sick all of the time with colds/flu and am a frequent visitor to the Endocrinologist, Immunologist and Dermatologist. Lupron has ruined my life both personally and financially.
Dec 31st, 2018
Someone from Albuquerque, NM writes:
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I was told Lupron would shut down my ovaries to relieve my pain. It shut down my major organs to live after the second injection. I almost had a stroke. If my dad wasn’t a Dr.,and prescribed me high blood pressure medicine, I probably wouldn’t be here. The worst pain I have ever experienced was from Lupron.My knees would give out on me, especially my right one. My hair was falling out, the cramps became worse . I didn’t stop vomiting from this drug for three months straight. I had to be on 5 weeks of iv therapy due to dehydration from my body rejecting this poison. I do not wish the pain I had on this drug upon anyone. There was a point this drug clouded my brain so bad I couldn’t even remember day to day activities. It was a nightmare being on Lupron.
Nov 27th, 2018
Debra H. from Lisbon, NY writes:
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I was told to “cure” my Endo I just had to try this drug..this was in the 80’s..I went through hell..now I have terrible joint problems..memory loss..etc..I’m scared.. This isn’t right that 40 yrs later ..this poison is still being pumped into women of all ages..some testimonies from girls as young as 12..doctors of course are receiving monies.vacations..etc..to pump poison.. Please..enough..it’s time for this pharmaceutical company to tell the truth..and pull this poison out of Endometriosis verbiage..
Nov 7th, 2018
K.D. O. from New York, NY writes:
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I took two trial of Lupron in 2008 and I have horrible memory loss. It’s started while being treated and was told that it would get better after treatments. It’s still difficult to retain almost any new information and impossible to recall old memories. My vision problems started around the same time; prior to treatment I had 20/20 vision.
Nov 7th, 2018
K.D. O. from New York, NY writes:
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I took two trial of Lupron in 2008 and I have horrible memory loss. It’s started while being treated and was told that it would get better after treatments. It’s still difficult to retain almost any new information and impossible to recall old memories. My vision problems started around the same time; prior to treatment I had 20/20 vision.
Nov 7th, 2018
K.D. O. from New York, NY writes:
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I took two trial of Lupron in 2008 and I have horrible memory loss. It’s started while being treated and was told that it would get better after treatments. It’s still difficult to retain almost any new information and impossible to recall old memories. My vision problems started around the same time; prior to treatment I had 20/20 vision.

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