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Investigation into Lupron Side Effects (Leuprolide Acetate)

Public Comments (5,065)
  • Feb 22nd, 2012
    Someone from Riverside, CA signed.
  • Feb 20th, 2012
    Someone from Walpole, MA writes:
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    Lupron causes cognitive impairment. Let's find out whether it is reversable. I'm not sure whether the side effects ever go away.
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  • Feb 20th, 2012
    Someone from Bel Air, MD signed.
  • Feb 20th, 2012
    Someone from Salt Lake City, UT writes:
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    4 1/2 years on this drug made my life hell! Research it before you use it. I was one of the first and at the age of 32 I was an 80 year old woman with my bones, energy level and weight gain.
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  • Feb 20th, 2012
    Someone from Soddy Daisy, TN writes:
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    I have suffered for 7 years with terrible joint pain after having 2 injections of Lupron, my doctor convinced me lupron was not the cause of the pain but after reading this article I know it was Lupron that changed my life and has made me feel disabled.
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  • Feb 19th, 2012
    Someone from Burlington, MA writes:
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    This drug needs to go away. It destroyed my life !
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  • Feb 17th, 2012
    Someone from Poway, CA signed.
  • Feb 17th, 2012
    Someone from Stone Lake, WI signed.
  • Feb 17th, 2012
    Someone from Memphis, TN writes:
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    I have personally been on Lupron, and The side effects are horrendous. The FDA should be ashamed as focus on the well being of the people, not the Large corporations making money. Who else has to suffer like I did???
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  • Feb 17th, 2012
    Someone from Poway, CA writes:
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    Brutal drug whose benefits, if any, do not outweigh the terrible longlasting side effects. Pretty sure those dr.s prescribing it have no in depth or personal knowledge of the pain involved long term. Drug manufacturer's monetary incentive must be really strong. The president of that co. must not have a wife or daughter whose severe bone pain is ripping through her body every day. A terminal cancer patient doesn't need this added pain. Did it help the endometriosis...No. Now suffering mmultiple health concerns.This drug should be removed from production.
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  • Feb 15th, 2012
    Someone from Portland, OR signed.
  • Feb 15th, 2012
    Someone from Charlotte, NC writes:
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    I took Lupron 9 years ago, as prescribed by my ob-gyn, for fibroids. I have suffered from tachycardia and insomnia since. The first tachycardia episode I have ever had occurred several hours after the first Lupron injection I ever had. The second tachycardia episode occurred several hours after the second Lupron injection. But the side effect never stopped. My last tachycardia episode was 3 days ago. I believe this is a dangerous drug.
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  • Feb 15th, 2012
    Someone from Chatfield, MN signed.
  • Feb 13th, 2012
    Someone from Madison, WI signed.
  • Feb 13th, 2012
    Someone from Santa Rosa, CA signed.
  • Feb 12th, 2012
    Someone from Wenonah, NJ writes:
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    i was pretty much forced into getting lupron injections right after i had surgery for endo and it made me feel so sick and my pain actually came right back. i kept telling the my doctor that i was having so many side effects missing work memory loss, etc but she made me go through with the 6 month treatment and actually tried to push me for 12 month treatment i never went back there. they never listened to me. lupron was the WORST "therapy" and two years later my body still isnt normal.
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  • Feb 12th, 2012
    Someone from Brookston, IN writes:
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    Take this off the market! It causes more pain than good!
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  • Feb 12th, 2012
    Someone from Fort Wayne, IN signed.
  • Feb 10th, 2012
    Someone from Fort Wayne, IN signed.
  • Feb 10th, 2012
    Someone from Fort Wayne, IN signed.
  • Feb 9th, 2012
    Someone from Columbus, GA signed.
  • Feb 9th, 2012
    Someone from Columbia City, IN signed.
  • Feb 9th, 2012
    Someone from Huntertown, IN signed.
  • Feb 9th, 2012
    Someone from Celina, OH signed.
  • Feb 9th, 2012
    Someone from Spokane, WA signed.
  • Feb 8th, 2012
    Someone from Geneseo, IL signed.
  • Feb 8th, 2012
    Someone from Andrews, IN signed.
  • Feb 8th, 2012
    Someone from Leo, IN signed.
  • Feb 8th, 2012
    Someone from Spokane, WA signed.
  • Feb 8th, 2012
    Someone from Fort Wayne, IN signed.
  • Feb 8th, 2012
    Someone from Huntington, IN signed.
  • Feb 8th, 2012
    Someone from Albuquerque, NM signed.
  • Feb 8th, 2012
    Someone from Harrison Township, MI signed.
  • Feb 8th, 2012
    Someone from Markle, IN signed.
  • Feb 7th, 2012
    Someone from Grimesland, NC signed.
  • Feb 7th, 2012
    Someone from Brooklyn, MD signed.
  • Feb 6th, 2012
    Someone from Nashville, TN signed.
  • Feb 6th, 2012
    Someone from Catonsville, MD writes:
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    I started Lupron in August of 2011 at the age of 49. I had previously been diagnosed with stage 1 breast cancer and was unable to take tamoxifin due to a history of a TIA. The first month I started Lupron, I noticed that I had an abundance of energy, a decrease of appetite, and trouble sleeping. About 1 week after my third month's shot, I lost my appetite completely and was only able to sleep for very short periods, if at all. I felt like I was "jumping out of my skin". I lost 10 pounds in a short period of time. My oncologist prescribed anti-anxiety and anti depressant medication to help me. He also recommended counseling and a psychiatric evaluation to rule out bipolar disorder or another mental health issue, despite my insistence that neither were the issue. The symptoms continued to the point where I felt the need to drive myself to the emergency room one night just to get something more to calm me. My thoughts had become scrambled to the point where I had difficulty functioning in my day-to-day activity. It felt as though I was on amphetamines. I was prescribed more anti-anxiety and anti-depressant drugs at the ER which helped minimally. The ER doctor also recommended counseling, despite my insistence that the only stress in my life at that point was the anti-estrogen treatment. By the end of the month, my symptoms had worn off and I discontinued all my medications, including the Lupron. My onocologist continued to think it was a "mental health issue" related to estrogen withdrawal. For this reason he was hesitant to recommend having my ovaries removed, as he felt a surgical menopause would be even worse for me. This was difficult for me as anti-estrogen treatment had been recommended to help prevent reccurence of my breast cancer. Fortunately, my oncologist encouraged me to seek a second opinion. The second opinion was from a doctor who was both a psychiatrist and breast oncologist. He felt, based on my symptoms, the Lupron had affected the hypothalamus of my brain causing hypomania. He recommended that my ovaries be removed, which I have since done. It has only been two weeks since having my ovaries removed, but the side effects that were so debilitating for me while on Lupron have not re-emerged. While I know it is still early, I am writing to say that there needs to be more information given to doctors about the possible side effects of this drug. That way, when a patient complains, they will be more informed.
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  • Feb 5th, 2012
    Someone from Palatine, IL signed.
  • Feb 4th, 2012
    Someone from Bel Air, MD signed.